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Suppression of Pentylenetetrazol‐Elicited Seizure Activity by Intraosseous Propranolol in Pigs
Author(s) -
Jim Kam F.,
Lathers Claire M.,
Spivey William H.,
Matthews William D.,
Kahn Clare,
Dolce Kathleen
Publication year - 1988
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/j.1552-4604.1988.tb05724.x
Subject(s) - propranolol , pentylenetetrazol , anesthesia , medicine , anticonvulsant , population , blood pressure , basal (medicine) , epilepsy , pharmacology , environmental health , psychiatry , insulin
The intraosseous (IO) route provides a rapid and effective alternative venous access in the pediatric population when the conventional intravenous (IV) route cannot be easily obtained. DL‐propranolol, a beta‐adrenoceptor antagonist, exhibits antiepileptic activity in various animal seizure models. This study assessed the efficacy of IO propranolol in suppressing pentylenetetrazol (PTZ)‐induced seizure activity in pigs. Domestic swine (13–20 kg) were prepared for recordings of arterial blood pressure, ECG and electrocortical activity. Seizure activity was induced by pentylenetetrazol (PTZ; 100 mg/kg; IV). Sixty seconds after the onset of seizure activity, the animals either received no drug (control) or propranolol (IV or IO via an 18‐gauge spinal needle placed in the right proximal tibia). A transient increase (16.3–50.0%) in the mean arterial blood pressure (MAP) was observed following PTZ administration. Both IO and IV propranolol significantly suppressed the seizure duration (SD) (sec/min interval) at 1 min following drug administration; SD control, 36.3 ± 4.8; IV propranolol, 12.3 ± 5.1; IO propranolol, 18.3 ± 6.0. In addition, both IV and IO propranolol produced a maximal decrease of 32–38% in the basal heart rate; and reduced the transient increase in MAP elicited by PTZ, with no significant effect on the basal MAP. The data demonstrate that 1) propranolol possesses anticonvulsant activity against PTZ‐induced seizure in the pig, and 2) the intraosseous route is a rapid and effective alternative venous access for propranolol administration in swine.