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The Hemodynamic Effects of Intravenous Ranitidine in Intensive Care Unit Patients: A Double‐Blind Prospective Study
Author(s) -
Onofrey David,
Kelly Kathleen M.,
Gentili David R.,
Benjamin Ernest,
Iberti Thomas J.
Publication year - 1988
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/j.1552-4604.1988.tb05722.x
Subject(s) - ranitidine , medicine , cimetidine , hemodynamics , anesthesia , intensive care unit , vascular resistance , blood pressure , intensive care , intensive care medicine
The hemodynamic effects of intravenous ranitidine were studied in a prospective double‐blind fashion in postoperative intensive care unit patients to determine if this H 2 blocker produced the same transient fall in mean arterial pressure and systemic vascular resistance known to occur with cimetidine infusion. We found no statistically significant hemodynamic changes from baseline associated with infusion of 50 mg ranitidine over a 5‐minute period. The different chemical ring structure of ranitidine and its effect on H 2 vascular and cardiac receptors may account for these observations.