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Preserved Renal Perfusion During Beta Blockade by Tertatolol with and without Cyclooxygenase Inhibition in Normal Humans
Author(s) -
Reuse Charles,
Leeman Marc,
Degaute JeanPaul,
Abramowicz Michel,
Prost JeanFrancois,
Naeije Robert
Publication year - 1988
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/j.1552-4604.1988.tb03149.x
Subject(s) - medicine , renal blood flow , hemodynamics , aspirin , kidney , placebo , renal function , renal circulation , heart rate , anesthesia , cardiac output , blood pressure , cardiology , pharmacology , pathology , alternative medicine
The systemic and renal hemodynamic effects of tertatolol, a new noncardioselective beta blocker without partial agonist activity, given alone or in combination with cyclooxygenase inhibition by acetylsalicylic acid (aspirin), were investigated in eight healthy volunteers. Tertatolol 5 mg, aspirin 1 g, tertatolol 5 mg together with aspirin 1 g and placebo were administered at 1‐week intervals in a random order and in a double‐blind fashion. Cardiac output was measured by Doppler echography and renal blood flow and glomerular filtration rate (GFR) by constant infusion techniques using ( 123 I) iodohippurate and ( 51 Cr) EDTA, respectively. Measurements were performed before and then successively 2 and 4 hours after oral intake of drugs or placebo. Tertatolol decreased cardiac output by 22% (P < .05) and heart rate by 17% (P < .05) without change in blood pressure, renal blood flow, and GFR. The same effects occurred when tertatolol was given together with aspirin. Either placebo or aspirin alone had no effect on systemic and renal hemodynamics. These results suggest that cardiac output is redistributed to the kidneys after tertatolol intake in normal humans. This favorable effect on renal hemodynamics is probably not mediated by a local release of vasodilating prostaglandins.