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Pentopril‐Cimetidine Interaction Caused by a Reduction in Hepatic Blood Flow
Author(s) -
Kochak Gregory M.,
Rakhit Ashok,
Thompson Thomas N.,
Hurley Margaret E.
Publication year - 1988
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/j.1552-4604.1988.tb03136.x
Subject(s) - cimetidine , pharmacokinetics , pharmacology , drug interaction , bioavailability , blockade , clearance , blood flow , oral administration , histamine h2 receptor , chemistry , medicine , receptor , antagonist , urology
The interactive effects of the coadministration of steady‐state Cimetidine and single‐dose pentopril, an angiotensin converting enzyme inhibitor, on the pharmacokinetic disposition of each other were studied in humans. Cimetidine reduced the clearance of pentopril by 11 to 14%. This reduction in clearance was shown to be caused by a reduction in liver blood flow probably mediated through H 2 receptor blockade. Meanwhile pentopril induced the oral clearance of Cimetidine by 21%, presumably by a reduction in the bioavailable fraction of Cimetidine. The mechanism of this interaction is unknown.