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Sleep Apnea Following Withdrawal of Amitriptyline
Author(s) -
Musa Mahmoud N.
Publication year - 1988
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/j.1552-4604.1988.tb03126.x
Subject(s) - amitriptyline , anesthesia , apnea , medicine , sleep (system call) , sleep apnea , central sleep apnea , breathing , nocturnal , polysomnography , computer science , operating system
A 41‐year‐old man developed sleep apnea following abrupt cessation of amitriptyline. Cessation of antidepressants may result in excessive release of acctylcholine, which increases REM sleep. This in turn increases disordered breathing time and decreases nocturnal oxygenation. Sleep apnea did not recur when amitriptyline was reinstated and later gradually discontinued.