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Verapamil and Lithium in Maintenance Therapy of Manic Patients
Author(s) -
Giannini A. James,
Taraszewski Robert,
Loiselle Robert H.
Publication year - 1987
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/j.1552-4604.1987.tb05600.x
Subject(s) - verapamil , lithium (medication) , medicine , lithium therapy , cardiology , pharmacology , intensive care medicine , bipolar disorder , calcium
A year‐long double‐blind cross‐over study was used to compare the long‐term therapeutic effects of lithium versus verapamil in a group of 20 manic volunteers. Subjects received each medication for six months. Before cross‐over, verapamil patients showed a significant improvement after 60 days, lithium‐treated patients after 180 days. After cross‐over, verapamil‐treated subjects showed improvement at day 240. Lithium‐treated patients showed no improvement after cross‐over. The data indicate that verapamil may be effective as an agent in the maintenance treatment of manic patients.