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Hemodynamic Effects During Rest and Exercise of Bucindolol in Hypertensive Men
Author(s) -
Conner Dale P.,
Vlasses Peter H.,
Clementi Regina A.,
Oren Arie,
Deitchman David,
Ferguson Roger K.
Publication year - 1987
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/j.1552-4604.1987.tb03018.x
Subject(s) - propranolol , heart rate , medicine , blood pressure , vascular resistance , placebo , vasodilation , forearm , cardiology , hemodynamics , crossover study , anesthesia , surgery , alternative medicine , pathology
Bucindolol is an investigational beta‐adrenergic blocking agent with intrinsic sympathomimetic and vasodilatory activity in animals. In a double‐blind, six‐way, crossover study of six mild‐to‐moderate hypertensive men, the effects of bucindolol 100, 200, and 300 mg/d on resting blood pressure, heart rate, forearm blood flow, and vascular resistance measured by pneumoplethysmography, and blood pressure and heart rate after cycle and handgrip exercise were compared with those of propranolol 160 and 320 mg/d and placebo after q12h administration for five doses. Both bucindolol and propranolol significantly suppressed heart rate after cycle exercise in comparison with placebo (−33 to −48 beats/min), demonstrating beta blockade. Suppression of resting heart rate by propranolol (−20 beats/min) was significantly ( P < .05) greater than bucindolol (−7 to −8 beats/min); a similar treatment difference in heart rate was noted after handgrip exercise (−18 to −19 vs −1 to −8 beats/min, respectively). Bucindolol and propranolol decreased resting blood pressure to the same extent (in comparison with placebo ; P < .05 at peak activity, 2 hr postdose). Bucindolol tended to increase forearm blood flow and decrease forearm vascular resistance ( P < .05 at 4 hr postdose) in comparison with placebo. The effect of propranolol on forearm blood flow and forearm vascular resistance was not significant compared with placebo. These data are consistent with intrinsic sympathomimetic and vasodilatory activity of bucindolol in hypertensive men .