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The Influence of Food on the Oral Absorption of Bevantolol
Author(s) -
Toothaker Roger D.,
Randinitis Edward J.,
Nelson Cynthia,
PhD Arlyn W. Kinkel,
Goulet J. Richard
Publication year - 1987
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/j.1552-4604.1987.tb03017.x
Subject(s) - bioavailability , ingestion , crossover study , absorption (acoustics) , absorption rate , drug , oral administration , absorption efficiency , pharmacology , pharmacokinetics , medicine , chemistry , zoology , biology , chromatography , materials science , alternative medicine , pathology , composite material , placebo
The bioavailability of bevantolol was compared in 12 healthy volunteers given single doses of the drug as the HCl salt after an overnight fast, or 15 minutes before or after a standardized breakfast in a nonblind, randomized crossover design. Bevantolol was rapidly absorbed in all three treatment groups, with maximum concentrations (C max ) observed at 1.0, 0.9, and 1.8 hours for the fasting, before breakfast, and after breakfast groups, respectively. Time to C max was significantly longer than fasting only when bevantolol was given after breakfast. Food ingestion did not significantly affect C max , total of absorbed drug, or the drug elimination rate. Since food only slightly decreases the drug absorption rate and has no measurable effect on the extent of drug absorption, the relationship of bevantolol administration to meals is not expected to influence therapeutic efficacy.