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The Effect of Once‐Daily Minoxidil on Blood Pressure and Plasma Lipids
Author(s) -
Johnson Brian F.,
Errichetti Ann,
Urbach David,
Hoch Kathleen,
Johnson Johanna
Publication year - 1986
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/j.1552-4604.1986.tb02947.x
Subject(s) - minoxidil , chlorthalidone , nadolol , blood pressure , medicine , supine position , cholesterol , diuretic , plasma renin activity , endocrinology , hydrochlorothiazide , heart rate , renin–angiotensin system , propranolol
Once‐daily minoxidil administration was added to the treatment regimen of 11 patients with hypertension that was inadequately controlled by nadolol 160 mg and chlorthalidone 50 mg given once daily. Additional diuretic therapy was needed by five patients. During treatment without minoxidil and at three and six months of maintenance minoxidil therapy, respectively, 24‐hour postdose supine blood pressure fell significantly ( P <.01) from 142 ± 19/96 ± 6 mm Hg to 132 ± 16/87 ± 4 and 131 ± 12/87 ± 4 mm Hg, and home recordings showed that minoxidil induced a mean increase of about 5 beats/min in heart rate. Resting plasma renin activity was not significantly altered. High‐density lipoprotein (HDL) cholesterol increased from 31.6 ± 9.9 to 35.2 ± 10.9 mg/dL ( P <.05) and to 34.4 ± 11.3 mg/dL (NS), and low‐density lipoprotein (LDL) cholesterol decreased from 146 ± 36 to 136 ± 32 mg/dL ( P <.05) and to 126 ± 35 mg/dL ( P <.01) over the same periods. At six months, approximately 20% changes in ratios of HDL cholesterol to either LDL or total cholesterol were seen. These changes occurred despite a three‐pound mean increase in body weight ( P <.05); these alterations are potentially beneficial in terms of reducing the estimated risk of coronary artery disease .