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Prophylaxis of Migraine Attacks With a Calcium‐Channel Blocker: Flunarizine Versus Methysergide
Author(s) -
Steardo Luca,
Marano Enrico,
Barone Paolo,
Denman Daniel W.,
Monteleone Palmiero,
Cardone Gennaro
Publication year - 1986
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/j.1552-4604.1986.tb02945.x
Subject(s) - flunarizine , methysergide , migraine , calcium channel blocker , medicine , anesthesia , migraine disorders , pharmacology , calcium , antagonist , receptor
In this study, flunarizine, a selective calcium‐channel blocker, was employed in the prophylactic treatment of headache and was compared with methysergide in terms of efficacy. The trial was conducted with 104 patients (53 treated with flunarizine and 51 treated with methysergide) and lasted six months—one month of pretreatment and five months of therapy. Patients in both groups experienced a highly significant reduction in the number and duration of migraine attacks. Unlike those in the methysergide group, patients treated with flunarizine achieved a significant reduction in the intensity of attacks with very negligible side effects.