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Graphic Methods in Pharmacokinetics: The Basics
Author(s) -
Welling Peter G.
Publication year - 1986
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/j.1552-4604.1986.tb02943.x
Subject(s) - pharmacokinetics , excretion , pharmacology , plasma concentration , distribution (mathematics) , drug , plasma levels , absorption (acoustics) , chemistry , medicine , mathematics , mathematical analysis , physics , acoustics
A considerable amount of information regarding the kinetics of drug absorption, distribution, metabolism, and excretion can be obtained by graphic analysis of plasma concentration and/or urinary excretion data. The simplest pharmacokinetic model is used to describe the analysis of drug concentration profiles in plasma after administration intravenous or nonvascular routes. Methods to calculate pharmacokinetic and pharmacologic parameters include urinary excretion rate, cumulative excretion, and the construction and analysis of Sigma‐minus plots. The treatment for this simple pharmacokinetic model provides a basis for graphic analysis of more complex models.