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Treatment of Depression in Chronic Cocaine and Phencyclidine Abuse With Desipramine
Author(s) -
Giannini A. James,
Malone Donald A.,
Giannini Matthew C.,
Price William A.,
Loiselle Robert H.
Publication year - 1986
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/j.1552-4604.1986.tb02936.x
Subject(s) - desipramine , phencyclidine , cocaine abuse , placebo , depression (economics) , medicine , substance abuse , psychiatry , anesthesia , psychology , antidepressant , anxiety , nmda receptor , receptor , alternative medicine , macroeconomics , pathology , economics
An open field trial was conducted comparing desipramine and an active placebo in separate populations of chronic cocaine and phencyclidine (PCP) abusers, who discontinued their abuse. Subjects who received desipramine showed a decrease in depressive symptoms after a 20–40 day period regardless of whether they abused PCP or cocaine.