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Effect of Transdermal Scopolamine on Salivation
Author(s) -
Gordon C.,
BenAryeh H.,
Attias J.,
Szargel R.,
Gutman D.
Publication year - 1985
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/j.1552-4604.1985.tb02867.x
Subject(s) - transdermal , scopolamine , potassium , chemistry , magnesium , placebo , sodium , atropine , pharmacology , parasympatholytic , saliva , medicine , anesthesia , biochemistry , alternative medicine , muscarinic acetylcholine receptor , receptor , organic chemistry , pathology
The effect of transdermal scopolamine on salivary flow and composition was analyzed in 21 healthy volunteers. The flow rate of whole saliva was significantly lowered by transdermal scopolamine. Significant positive correlations were found between the placebo rate of flow and both the quantity and percentage decreases in response to transdermal scopolamine. The magnesium concentration was significantly increased during transdermal scopolamine administration, whereas the sodium, potassium, and calcium concentrations were not consistently altered. Accordingly, the magnesium secretion rate was unaltered, whereas sodium, potassium, and calcium secretion rates were significantly lowered by transdermal scopolamine administration.