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The Effect of Rapid Digitalization on Ventricular Function in Patients With Congestive Heart Failure
Author(s) -
Rotenberg Zvi,
Hellman Chaim,
Weinberger Itzhak,
Fuchs Jacob,
Agmon Jacob
Publication year - 1985
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/j.1552-4604.1985.tb02860.x
Subject(s) - heart failure , digitalis , cardiology , medicine , contractility , ventricular pressure , cardiac function curve , ventricular function , diastole , blood pressure , aortic pressure
Cardiac glycosides have been used in the treatment of cardiac failure for more than 200 years. Digitalis and its analogues have been shown to increase myocardial contractility and to decrease left ventricular end‐diastolic pressure and volume, while causing no essential change in aortic pressure and a variable decrease in heart rate. 1–2 However, several reports 3–8 have questioned the use of digitalis in patients with ventricular dysfunction, particularly in view of the newer modes of therapy. The aim of this study was to define the effects of rapid digitalization on left and right ventricular function in patients with chronic congestive heart failure, using radionuclide methods.