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A Comparative Oral Analgesic Study of Indoprofen, Aspirin, and Placebo in Postpartum Pain
Author(s) -
Sunshine Abraham,
Zighelboim Itic,
Olson Nancy Z.,
Sarrazin Cherokee,
Laska Eugene
Publication year - 1985
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/j.1552-4604.1985.tb02858.x
Subject(s) - medicine , aspirin , analgesic , placebo , anesthesia , alternative medicine , pathology
The purpose of this study was to evaluate the analgesic efficacy and adverse effect liability of single oral doses of indoprofen, 50 mg, 100 mg, and 200 mg, compared with aspirin, 300 mg and 600 mg, and placebo in the relief of moderate to severe postpartum pain. Two hundred‐ten patients entered a randomized, double‐blind, parallel group study and were evaluated over a six‐hour period by a single nurse‐observer. There was a significant imbalance in the distribution of pain types across treatments that compromises the interpretation of the results. In addition to analyzing the data from all patients, the subsets with episiotomy/cesarean section pain and uterine cramp pain were examined separately. The latter group had too few patients to permit distinction between drugs. The 100 mg and 200 mg doses of indoprofen were significantly ( P .05) more effective than placebo for many variables including the following summary values: sum of pain intensity difference (SPID), sum of hourly relief values (TOTPAR), and % SPID for all patients as well as in the subset of patients with episiotomy/cesarean section pain. Aspirin, 600 mg, was also significantly more effective than placebo for many of the same measures of analgesia in the episiotomy/cesarean section subset. Pairwise differences were also seen between placebo and aspirin, 300 mg, but on fewer variables. Indoprofen, 100 mg, was significantly more effective than aspirin, 600 mg, at hour 6 for pain intensity difference (PID) in the episiotomy/cesarean section subset. The effect of indoprofen appeared to plateau above 100 mg. The relative potency estimates of indoprofen to aspirin ranged from seven to ten for the variables SPID, TOTPAR, and % SPID. There were no observed or reported adverse effects. In summary, indoprofen was found to be an effective oral analgesic similar to aspirin, with the suggestion of a more sustained effect .