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Indenolol: A New Antihypertensive Agent: Efficacy, Toxicity, and Hemodynamic Effects in a Crossover Double‐Blind Study With Metoprolol
Author(s) -
Trimarco Bruno,
Cuocolo Alberto,
Groothold Gisela,
Ricciardelli Bruno,
Luca Nicola,
Volpe Massimo,
Veniero Anna Maria,
Condorelli Mario
Publication year - 1985
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/j.1552-4604.1985.tb02850.x
Subject(s) - metoprolol , medicine , crossover study , hemodynamics , cardiac output , blood pressure , heart rate , cardiology , stroke volume , ejection fraction , ventricle , placebo , anesthesia , cardiac index , basal (medicine) , heart failure , alternative medicine , pathology , insulin
The antihypertensive efficacy of a new agent, indenolol, was compared with that of the well‐established antihypertensive drug, metoprolol, and its hemodynamic effects were investigated using echocardiography. Eighteen hypertensives completed a double‐blind, crossover, randomized study using indenolol and metoprolol. Two four‐week courses with indenolol or metoprolol were preceded and followed by a two‐week placebo period; the total duration of the study was 14 weeks. Indenolol proved to be significantly more effective than metoprolol in decreasing blood pressure values at rest ( P < .05). Furthermore, three patients that failed with metoprolol were successfully treated with indenolol. Both drugs induced a significant decrease in cardiac output that was mediated mainly through a reduction in heart rate, because stroke volume, left ventricle circumferential fiber shortening velocity, and ejection fraction were not significantly reduced by either drug. However, after indenolol, a significant direct relationship was found between the basal values of both cardiac output ( r = .809) and total peripheral resistance ( r = .800), and the reduction of these parameters. On the contrary, after metoprolol only, the correlation between the basal value of cardiac output and its reduction was significant ( r = .790) .