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Neuroleptic Bioequivalency: Tablet Versus Concentrate
Author(s) -
Fann W.E.,
Moreira Alvaro F.
Publication year - 1985
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/j.1552-4604.1985.tb02844.x
Subject(s) - bioavailability , dosing , antipsychotic , pharmacology , pharmacokinetics , medicine , oral administration , antipsychotic agent , antipsychotic drug , anesthesia , schizophrenia (object oriented programming) , psychiatry
Two forms of the antipsychotic neuroleptic molindone were administered to newly admitted psychotic patients. A coated tablet was administered for ten days, followed by administration of liquid concentrate in equivalent doses for four days. Plasma was analyzed by gas chromatography with electron capture for the parent compound following each dosing phase. Our data suggest that oral doses of the tablet and concentrate forms of this neuroleptic are equivalent in clinical bioavailability.