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Methyldopa Does Not Alter the Disposition of Digoxin
Author(s) -
MAY CAROL A.,
VLASSES PETER H.,
ROCCI MARIO L.,
ROTMENSCH HESCHI H.,
SWANSON BRIAN N.,
TANNENBAUM RENEE P.,
FERGUSON ROGER K.,
ABRAMS WILLIAM B.
Publication year - 1984
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/j.1552-4604.1984.tb02791.x
Subject(s) - digoxin , pharmacokinetics , placebo , medicine , urine , methyldopa , disposition , drug interaction , pharmacology , endocrinology , chemistry , heart failure , blood pressure , psychology , social psychology , alternative medicine , pathology
R ecent reports have documented interactions between digoxin and agents with dissimilar chemical structures, including quinidine, 1–3 nifedipine, 4 verapamil, 5,6 and amiodarone. 7,8 Concomitant use of these agents with digoxin has resulted in increased serum concentrations and, in some cases, clinical signs and symptoms of digoxin toxicity. On this basis, the Food and Drug Administration has proposed that future New Drug Applications for drugs that have projected use in the elderly should contain evaluations of digoxin interactions. Methyldopa (Aldomet, Merck Sharp & Dohme) is a commonly prescribed antihypertensive agent which is frequently administered concomitantly with digoxin. The purpose of this study was to evaluate whether methyldopa alters the disposition of digoxin in normal volunteers.