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A Controlled Endoscopic Study Comparing the Toxic Effects of Sulindac, Naproxen, Aspirin, and Placebo on the Gastric Mucosa of Healthy Volunteers
Author(s) -
LANZA FRANK L.,
NELSON ROBERT S.,
RACK MARY FRANCES
Publication year - 1984
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/j.1552-4604.1984.tb02770.x
Subject(s) - sulindac , naproxen , aspirin , medicine , placebo , gastric mucosa , gastroenterology , stomach , nonsteroidal , pathology , alternative medicine
Sixty volunteers were endoscopically evaluated to compare gastric mucosal injury following oral administration of sulindac, naproxen, aspirin, or placebo for two consecutive seven‐day periods. A single‐blind technique was utilized wherein the endoscopist was unaware which drug each volunteer had received. The following dosages were employed for the two study periods: sulindac, 150 and 200 mg, b.i.d., naproxen, 250 and 375 mg, b.i.d., and aspirin, 650 and 975 mg, q.i.d. The only subject who developed a frank ulcer with mucosal bleeding was in the sulindac group, however volunteers taking sulindac demonstrated statistically less significant mucosal injury on endoscopic examination than those receiving naproxen or aspirin.