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The Clearance of Cyclosporine by Hemodialysis
Author(s) -
VENKATARAMANAN RAMAN,
PTACHCINSKI RICHARD J.,
BURCKART GILBERT J.,
YANG SHIN L.,
STARZL THOMAS E.,
THEIL DAVID H.
Publication year - 1984
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/j.1552-4604.1984.tb02763.x
Subject(s) - hemodialysis , pharmacokinetics , medicine , dialysis , metabolic clearance rate , plasma clearance , clearance , clearance rate , urology , cyclosporins , pharmacology , transplantation
The pharmacokinetics of cyclosporine were studied in five liver transplant patients when they were on and off hemodialysis. There was no significant difference in the blood clearance of cyclosporine between these two periods. Less than 1 per cent of the dose of cyclosporine was recovered in the dialysate. The mean dialysis clearance was less than 1 ml/min. This represents less than 1 per cent of the total blood clearance of cyclosporine. Dosage alterations of cyclosporine during or after hemodialysis do not appear to be necessary.