Premium
Effect of the Surface Area of Activated Charcoal on Theophylline Clearance
Author(s) -
PARK GLEN D.,
SPECTOR REYNOLD,
GOLDBERG MARK J.,
JOHNSON GEORGE F.,
FELDMAN ROSS,
QUEE CONNIE K.
Publication year - 1984
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/j.1552-4604.1984.tb01835.x
Subject(s) - theophylline , activated charcoal , charcoal , aminophylline , liter , chemistry , body surface area , regimen , zoology , pharmacology , medicine , anesthesia , biology , adsorption , organic chemistry
The effect of the surface area of activated charcoal on theophylline clearance was studied. Eight fasting, healthy men received intravenous infusions of either aminophylline (6 mg/kg, N = 3) or theophylline (5 mg/kg, N = 5) over 1 hour followed by either 5 Gm standard activated charcoal every 2 hours, 20 Gm every 2 hours, or 5 Gm PX‐21 activated charcoal (with 3.6 times the surface area) every 2 hours. Theophylline t 1/2 and AUC with each regimen were respectively 6.3 ± 0.5 (S.E.) hours and 88.9 ± 8.4 mg/liter · hr with 5 Gm standard activated charcoal, 5.3 ± 0.3 hours and 75.4 ± 4.9 mg/liter · hr with 5 Gm PX‐21, and 4.9 ± 0.2 hours and 67.7 ± 3.6 mg/liter · hr with 20 Gm standard activated charcoal. There was a relationship between the activated charcoal surface area and the reduction in theophylline t 1/2 and AUC. We conclude that the clearance of theophylline is related to the surface area of activated charcoal administered and that PX‐21 may be a more potent activated charcoal product for enhancing theophylline removal.