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Comparison of Haloperidol and Chlorpromazine in the Treatment of Phencyclidine Psychosis
Author(s) -
GIANNINI A. JAMES,
EIGHAN MICHAEL S.,
LOISELLE ROBERT H.,
GIANNINI MATTHEW C.
Publication year - 1984
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/j.1552-4604.1984.tb01831.x
Subject(s) - phencyclidine , haloperidol , chlorpromazine , psychosis , antipsychotic , pharmacology , schizophrenia (object oriented programming) , blockade , medicine , dopamine antagonist , dopamine , psychology , receptor , anesthesia , psychiatry , nmda receptor
T wo neuroleptics, haloperidol and chlorpromazine, have been reported to be effective in the treatment of phencyclidine (PCP) psychosis. Both neuroleptics are thought to exert their antipsychotic PCP effects by blockade of central dopamine receptors. They have been studied extensively in animal populations and less extensively in human populations. There has, however, been no comparison of their relative effects in human populations. We describe such a study below.