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Myocardial Metabolic Effects of Intravenous Terbutaline in Patients with Severe Heart Failure Due to Coronary Artery Disease
Author(s) -
WANG REBECCA Y. C.,
LEE PUI K.,
YU DONALD Y. C.,
TSE TAK F.,
CHOW MOSES S. S.
Publication year - 1983
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/j.1552-4604.1983.tb02749.x
Subject(s) - medicine , terbutaline , cardiac index , cardiology , heart failure , coronary artery disease , pulmonary wedge pressure , hemodynamics , vascular resistance , coronary sinus , anesthesia , angina , artery , cardiac output , myocardial infarction , asthma
Intravenous terbutaline, 0.3 mg/kg/min for 30 minutes followed by 0.15 mg/min for 60 minutes, was studied in nine patients with severe heart failure due to documented coronary artery disease. Hemodynamic and myocardial metabolic effects were measured during terbutaline infusion. Cardiac index and stroke index increased, whereas mean pulmonary artery wedge pressure and pulmonary vascular resistance decreased significantly. No significant alterations in aortic oxygen content, coronary sinus oxygen content, myocardial oxygen extraction, and myocardial lactate extraction were observed during terbutaline infusion. No patient developed angina or electrocardiographic changes suggestive of ischemia. These results indicate that intravenous terbutaline infusion, at the dosage employed, produces beneficial hemodynamic effects without a deterioration of myocardial metabolism in patients with heart failure due to coronary artery disease.