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Cimetidine Disposition in Patients Undergoing Continuous Ambulatory Peritoneal Dialysis
Author(s) -
KOGAN FREDERICK J.,
SAMPLINER RICHARD E.,
MAYERSOHN MICHAEL,
KAZAMA RODNEY M.,
PERRIER DONALD,
JONES WILLIAM,
MICHAEL ULRICH F.
Publication year - 1983
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/j.1552-4604.1983.tb02732.x
Subject(s) - medicine , continuous ambulatory peritoneal dialysis , cimetidine , dosing , dialysis , peritoneal dialysis , pharmacokinetics , ambulatory , regimen , anesthesia , surgery
Cimetidine disposition was determined in six patients undergoing continuous ambulatory peritoneal dialysis to ascertain the need for modification of conventional dosing regimens. Blood, dialysis fluid, and urine were collected for 48 hours after administration of a single intravenous dose of cimetidine. The following values were obtained: elimination half‐life, 4.3 hours; systemic or total body clearance, 191 ± 55 ml/min; and dialysis clearance, 4.2 ± 3.1 ml/min. Approximately 2% of a cimetidine dose is removed by dialysis, indicating that there is no need to adjust the conventional renal failure dosing regimen in patients undergoing continuous ambulatory peritoneal dialysis.