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Opposite Effects on Human Distal Colon Motility of Two Postulated Alpha 2 ‐Antagonists (Mianserin and Chlorprothixene) and One Alpha 2 ‐Agonist (Clonidine)
Author(s) -
LECHIN FUAD,
DIJS BERTHA van der
Publication year - 1983
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/j.1552-4604.1983.tb02727.x
Subject(s) - clonidine , mianserin , agonist , alpha 2 adrenergic receptor , alpha (finance) , motility , pharmacology , tone (literature) , medicine , chemistry , endocrinology , anesthesia , receptor , serotonin , biology , surgery , construct validity , genetics , art , literature , patient satisfaction
The effects of two postulated alpha 2 ‐antagonists (mianserin and chlorprothixene) and an accepted alpha 2 ‐agonist (clonidine) on the distal colon motility in five healthy subjects were investigated. Opposite effects were induced by these two kinds of drugs. Distinct and characteristic motility responses were obtained from subjects with low distal colon tone and subjects with high distal colon tone. In addition, different and typical behavior responses paralleled motility changes in the two types of subjects. These results suggest that, at the doses employed in this study, both mianserin and chlorprothixene behave as alpha 2 ‐antagonists when tested on human distal colon motility against a known alpha 2 ‐agonist such as clonidine.