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Comparison of Bronchial Effects of Nabilone and Terbutaline in Healthy and Asthmatic Subjects
Author(s) -
GONG HENRY,
TASHKIN DONALD P.,
CALVARESE BARRY
Publication year - 1983
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/j.1552-4604.1983.tb02715.x
Subject(s) - bronchodilation , terbutaline , placebo , medicine , asthma , bronchodilator , anesthesia , tetrahydrocannabinol , cannabinoid , alternative medicine , receptor , pathology
The acute bronchomotor effect of nabilone, a synthetic cannabinoid compound, was compared to that of terbutaline sulfate and placebo in six healthy and six asthmatic subjects. Bronchodilation following nabilone was intermediate between that of terbutaline and placebo in the healthy subjects but was equivalent to placebo in the asthmatics. We conclude that oral nabilone (2 mg) does not result in significant acute bronchodilation in patients with asthma.