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Inhibitory Effect of Isoniazid on Antipyrine Clearance in Man
Author(s) -
GRECHBELANGER ODETTE,
BELANGER PIERREM.,
LACHANCE JOHANNE
Publication year - 1983
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/j.1552-4604.1983.tb01801.x
Subject(s) - isoniazid , concomitant , pharmacology , drug , drug metabolism , chemistry , drug interaction , medicine , liver enzyme , pharmacokinetics , hepatic dysfunction , pathology , tuberculosis
The effect of both concomitant administration and pretreatment with isoniazid on the activity of the hepatic drug‐metabolizing enzymes of healthy young volunteers, as indicated by the antipyrine clearance test, is reported. Concomitant administration of isoniazid with antipyrine results in a significant decrease in the hepatic clearance of the latter compound. In contrast, pretreatment for 14 days with isoniazid had no effect on antipyrine elimination kinetics. It is concluded that isoniazid depresses hepatic drug metabolism only when present in significant amounts at the hepatic site of drug oxidation.