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Food Increases the Bioavailability of Isotretinoin
Author(s) -
COLBURN WAYNE A.,
GIBSON D. M.,
WIENS R. E.,
HANIGAN J. J.
Publication year - 1983
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/j.1552-4604.1983.tb01800.x
Subject(s) - bioavailability , isotretinoin , crossover study , meal , medicine , washout , oral administration , pharmacokinetics , pharmacology , bioequivalence , zoology , acne , dermatology , biology , alternative medicine , pathology , placebo
Twenty healthy male subjects received 80 mg (2 × 40 mg SEG capsules) oral isotretinoin separated by two‐week washout periods in an open randomized crossover design. Isotretinoin was administered during a complete fast, 1 hour after a standard breakfast, with a standard breakfast, or 1 hour before a standard breakfast. Blood samples were obtained at specific times over a 72‐hour period. Isotretinoin blood concentrations were determined by a specific HPLC method. The relative bioavailability (AUC) of isotretinoin was found to be approximately 1.5 to 2 times greater when the dose was administered 1 hour before, concomitantly with, or 1 hour after a meal than when it was given during a complete fast. In addition, because the C max , value is lower when the dose is administered with food rather than 1 hour after a meal, coadministration of isotretinoin with food may be the best method of administration.