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The Effect of Acute and Chronic Renal Failure on Theophylline Clearance
Author(s) -
BAUER LARRY A.,
BAUER STEPHANIE PATTERSON,
BLOUIN ROBERT A.
Publication year - 1982
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/j.1552-4604.1982.tb05710.x
Subject(s) - theophylline , medicine , uremia , chronic renal failure , heart failure , renal function , bronchodilator , kidney disease , chronic renal disease , anesthesia , urology , cardiology , asthma
Theophylline total body clearance was measured in 29 anuric, chronic obstructive pulmonary disease patients with acute or chronic renal failure during a continuous intravenous infusion. They were divided into two groups depending on the absence (group 1, N = 16) or presence (group 2, N = 13) of congestive heart failure and compared to normal renal function control patients with similar disease states. All study and control patients smoked cigarettes. The theophylline mean total body clearance values (± S.D.) for group 1 were 68.0 ± 14.6, 64.5 ± 12.9, and 62.6 ± 17.3 ml/kg·hr for acute renal failure patients, uremic chronic renal failure patients, and control patients, respectively. For group 2, the corresponding values were 25.6 ± 6.1, 28.6 ± 8.7, and 27.4 ± 12.9 ml/kg·hr. There was no significant difference between study and control patients in either group 1 or group 2 ( P greater than 0.05, one‐way analysis of variance). Since total body clearance determines the steady‐state concentration of a drug after repeated administration, theophylline doses do not need to be reduced in acute renal failure or uremia patients.