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Saline Catharsis: Effect on Aspirin Bioavailability in Combination with Activated Charcoal
Author(s) -
SKETRIS INGRID S.,
MOWRY JAMES B.,
CZAJKA PETER A.,
ANDERSON WILLIAM H.,
STAFFORD DAVID T.
Publication year - 1982
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/j.1552-4604.1982.tb05709.x
Subject(s) - activated charcoal , bioavailability , chemistry , saline , aspirin , charcoal , sodium salicylate , absorption (acoustics) , zoology , pharmacology , medicine , biochemistry , adsorption , physics , organic chemistry , acoustics , biology
The effect of a saline cathartic combined with activated charcoal or activated charcoal alone on aspirin bioavailability was characterized in six healthy volunteers. Using a random, Latin‐square design, subjects were given 975 mg aspirin followed by either water alone, 15 Gm activated charcoal (AC), or 15 Gm activated charcoal plus 20 Gm sodium sulfate (AC + SS) separated by one week. Both AC (44.16 ± 16.85 μg/ml) and AC + SS (58.61 ± 10.63 μg/ml) decreased ( P < 0.001) the maximal plasma salicylate concentration ( C p max) compared to control (86.61 ± 12.69 μg/ml). Urinary salicylate recovery was decreased ( P < 0.01) for AC (57.88 ± 16.26 per cent) and AC + SS (61.00 ± 11.49 per cent) as compared to control (93.73 ± 6.83 per cent), while for area under the plasma concentration‐time curve ( AUC ) only AC showed a decrease ( P < 0.01) compared to control. Neither AC nor AC + SS differed from each other for C p max, AUC , or cumulative urinary recovery. Our findings indicate that the addition of sodium sulfate to activated charcoal has no added effect on limiting aspirin absorption relative to activated charcoal alone.