Premium
Hydrochlorothiazide Pharmacokinetics and Pharmacologic Effect: The Influence of Indomethacin
Author(s) -
WILLIAMS ROGER L.,
DAVIES RICHARD O.,
BERMAN RAYANNE S.,
HOLMES GEOFFREY I.,
HUBER PAUL,
GEE WINNIE LIANG,
LIN EMIL T.,
BENET LESLIE Z.
Publication year - 1982
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/j.1552-4604.1982.tb05705.x
Subject(s) - hydrochlorothiazide , chlorothiazide , diuretic , pharmacology , pharmacokinetics , probenecid , furosemide , medicine , drug , dosing , thiazide , drug interaction , absorption (acoustics) , endocrinology , blood pressure , physics , acoustics
It is known that nonsteroidal antiinflammatory drugs such as indomethacin can attenuate the pharmacologic effect of loop diuretics such as furosemide and ethacrynic acid and that indomethacin may also reduce the pharmacologic response to chlorothiazide. To examine further this potential drug—drug interaction, we administered 50‐ and 100‐mg single oral doses of hydrochlorothiazide with and without indomethacin to 10 healthy, normal subjects. We observed no significant influence of indomethacin either on the pharmacokinetics of hydrochlorothiazide or the pharmacologic response to this diuretic. The absorption and disposition of hydrochlorothiazide demonstrate that this drug is rapidly absorbed and produces a diuretic and natriuretic response that peaks at approximately 2 hours after dosing and is essentially terminated 12 hours after dosing. There appeared to be no greater pharmacologic response to the 100‐mg than to the 50‐mg hydrochlorothiazide dose in the ten subjects in this study.