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Effect of Furosemide on the Pharmacokinetics of Gentamicin in Patients
Author(s) -
LAWSON D. H.,
TILSTONE W. J.,
GRAY J. M. B.,
SRIVASTAVA P. K.
Publication year - 1982
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/j.1552-4604.1982.tb02670.x
Subject(s) - furosemide , gentamicin , nephrotoxicity , renal function , pharmacokinetics , medicine , plasma clearance , diuretic , metabolic clearance rate , clearance , aminoglycoside , pharmacology , urology , anesthesia , kidney , chemistry , antibiotics , biochemistry
The clearances of inulin and gentamicin were studied before and after intravenous furosemide in seven patients. There was a significant fall in glomerular filtration rate after furosemide and a similar though less marked fall in gentamicin clearance in six of the seven subjects. Small but consistent increases in plasma gentamicin concentrations were observed after furosemide. The reduction in clearance may explain the enhanced risk of nephrotoxicity in patients receiving both aminoglycosides and diuretics.