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Metaproterenol Solution in the Treatment of Asthmatic Patients by Intermittent Positive Pressure Breathing
Author(s) -
BRANSCOMB BEN V.
Publication year - 1982
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/j.1552-4604.1982.tb02666.x
Subject(s) - medicine , anesthesia , intermittent positive pressure breathing , placebo , crossover study , pulmonary function testing , asthma , blood pressure , alternative medicine , pathology
The effects of five different doses of a 5% inhalant solution of metaproterenol on pulmonary function were compared in a placebo‐controlled double‐blind crossover study in 40 asthmatic patients who received the drug via intermittent positive pressure breathing (IPPB). The response to metaproterenol in terms of FVC, FEV 1 , RA , and FEF 25–75% was significantly superior to the placebo response. The effect of metaproterenol set in within 5 minutes of administration, and clinically significant improvement in pulmonary function was sustained for 6 hours even at the lowest dose level. Global response evaluations reflected a progressive increase in effectiveness with each successive dose increment. Typical sympathomimetic side effects such as nervousness and shakiness slightly increased in frequency with higher doses. At none of the metaproterenol doses were any clinically significant changes observed in the mean blood pressure and pulse rate values.