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Bioavailability of Organic Nitrates: A Comparison of Methods for Evaluating Plethysmographic Responses
Author(s) -
HAFFTY BRUCE G.,
NAKAMURA YASUYUKI,
LONG ROBERT A.,
HULL J. HEYWARD,
SPODICK DAVID H.
Publication year - 1982
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/j.1552-4604.1982.tb02658.x
Subject(s) - bioavailability , plethysmograph , pharmacology , medicine , environmental science , environmental chemistry , chemistry
Erythrityl tetranitrate, a long‐acting organic nitrate, was compared with isosorbide dinitrate in a double‐blind, placebo‐controlled complete crossover study in 15 healthy male volunteers. A digital plethysmogram and ear densitogram were used to assess the physiologic response to these two sublingual nitrates, with the intensity and duration of drug effect calculated by differences in diastolic amplitude intensity before and after drug administration. Both 5 mg sublingual erythrityl tetranitrate and 5 mg isosorbide dinitrate produced significant increases in diastolic amplitude intensity for up to 3 hours. The erythrityl tetranitrate peak effect was less than that of the isosorbide dinitrate, but the incidence of headaches was also less. The ear densitogram was found to be an effective means of assessing the diastolic amplitude intensity changes.