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Factors Moderating the Effect of Oral Sulfonylureas on Free Water Clearance
Author(s) -
DAVIS FAITH B.,
BOH DAWN M.,
DAVIS PAUL J.,
SON ALLENE R.,
MYLOTTE KATHLEEN M.,
EDWARDS LEILA,
ZIELEZNY MARIA,
SCZUPAK CHRISTINE
Publication year - 1982
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/j.1552-4604.1982.tb02655.x
Subject(s) - chlorpropamide , diuresis , medicine , endocrinology , diuretic , thiazide , antidiuretic , hyponatremia , free water clearance , diabetes mellitus , renal function , hormone
The effects of the antidiuretic agent chlorpropamide and the diuretic agent tolazamide on solute‐free water clearance ( C H 2 O) were compared in noninsulin‐dependent diabetic patients undergoing water diuresis. Hyperglycmia (fasting serum glucose above 200 mg/dl) obscured the effects of these two sulfonylureas on C H 2 O. Thiazide or ethacrynic acid enhancement of chlorpropamide antidiuresis was also blunted by hyperglycemia and attendant osmotic diuresis. Thus, the low incidence of symptomatic hyponatremia during chlorpropamide treatment of diabetic patients may be explained by persistent hyperglycemia in such patients.