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Plasma Pharmacokinetics of Intravenously Administered Atropine in Normal Human Subjects
Author(s) -
ADAMS RICHARD G.,
VERMA PRITAM,
JACKSON ANDRE J.,
MILLER RUSSELL L.
Publication year - 1982
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/j.1552-4604.1982.tb02638.x
Subject(s) - pharmacokinetics , atropine , pharmacology , medicine , metabolic clearance rate , plasma clearance , anesthesia
The pharmacokinetics of atropine ( dl ‐hyoscyamine) was studied in six normal volunteers following a single 1‐mg intravenous dose of atropine. Atropine plasma levels were collected for 24 hours and analyzed by radioimmunoassay. Pulse rates were monitored and compared with predose values in each subject. Atropine plasma concentrations were fitted by least‐squares regression analysis. The observed maximal increase in pulse rate, at 12 to 16 minutes after the dose, correlated with the maximum predicted tissue levels of atropine based on the computer fit of the plasma atropine concentration‐time data. No correlation between the time of maximum response and atropine plasma concentrations was observed. The average half‐life of atropine was 4.125 hours. This data may be used to design a multiple‐dosing regimen for intravenous atropine in patients.