Premium
Acute Pharmacodynamics and Pharmacokinetics of Oral Amrinone
Author(s) -
BENOTTI JOSEPH R.,
LESKO LAWRENCE J.,
McCUE JANE E.
Publication year - 1982
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/j.1552-4604.1982.tb02631.x
Subject(s) - amrinone , pharmacokinetics , pharmacodynamics , medicine , pharmacology , heart failure
Amrinone was administered orally as a single 100‐mg dose to six male patients with moderate‐severe congestive heart failure to determine the acute pharmacodynamic effects and pharmacokinetics of the drug. Following right heart catherization and amrinone administration, measurements of hemodynamic parameters including cardiac index (CI), right atrial pressure (RA), pulmonary capillary wedge pressure (PCW), and serum amrinone concentrations (SAC) were made at hourly intervals for up to 8 hours. CI increased (29.0 per cent) significantly ( P < 0.05) at 3 hours after dose. PCW declined quickly after dose and was significantly ( P < 0.05) lower (–31.3 per cent) than control at 3 hours. RA declined gradually, and a significant ( P < 0.05) reduction (–25.2 per cent) was achieved 5 hours after the dose. Amrinone was absorbed quickly (t max = 1.4 hour), and the disappearance of amrinone from serum was log‐linear (t ½ = 5.1 hours). The time courses of per cent change in CI and SAC were similar, and the correlation between the average per cent change in CI and average SAC was linear and significant ( r = 0.80; P < 0.05).