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Gastrointestinal Blood Loss of Oxaprozin and Aspirin with Placebo Control
Author(s) -
LUSSIER ANDRÉ,
LeBEL ÉTIENNE,
TÉTREAULT LÉON
Publication year - 1982
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/j.1552-4604.1982.tb02159.x
Subject(s) - placebo , aspirin , medicine , analysis of variance , placebo group , anesthesia , significant difference , gastroenterology , surgery , alternative medicine , pathology
The objective of this study was to compare the effects of oxaprozin (4,5‐diphenyl‐2‐oxazolepropionic acid), a nonsteroidal, antiinflammatory compound, and aspirin in a double‐blind, placebo‐controlled study to estimate gastrointestinal bleeding. The determination of fecal blood loss was made quantitatively by the use of the radioactive ( 51 Cr) technique. During the first week, subjects were controlled with and without placebo. At the end of the second week, the subjects were divided and randomly assigned to one of three groups; 10 received 1200 mg oxaprozin (600 mg twice daily), 11 received 3900 mg aspirin (975 mg four times a day), and the remaining 8 subjects received placebo for two weeks. During the last two weeks, all received placebo again. A statistical analysis of variance showed that there were no statistical differences between the groups during the first and last two weeks of placebo therapy. During the active treatment period, weeks 3 and 4, there were statistically significant differences among the three groups. The mean blood loss during week 3 was significantly greater for the aspirin group, 8.8 ml/day, than the oxaprozin group, 3.3 ml/day ( P < 0.05), and the placebo group, 1.4 ml/day ( P < 0.001). The smaller difference between oxaprozin and placebo was also significant ( P < 0.05). During the fourth week, the mean daily blood loss among oxaprozin patients had decreased to 2.3 ml/day, and no statistically significant difference from placebo (1.1 ml/day) was found.