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The Oral Analgesic Efficacy of Bicifadine Hydrochloride in Postoperative Pain
Author(s) -
WANG RICHARD I. H.,
JOHNSON ROGER P.,
LEE JOHN C. M.,
WAITE ELIZABETH M.
Publication year - 1982
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/j.1552-4604.1982.tb02157.x
Subject(s) - analgesic , placebo , medicine , aspirin , anesthesia , significant difference , alternative medicine , pathology
Abstract: The analgesic efficacy of 75 and 150 mg bicifadine hydrochloride was compared to 650 mg aspirin and placebo in a double‐blind, single‐dose study. Oral doses were administered to 100 patients suffering from moderate to severe postoperative pain. Significant analgesic activity was demonstrated with 650 mg aspirin and 150 mg bicifadine as compared to 75 mg bicifadine or placebo. No significant treatment difference was found between 75 mg bicifadine and placebo. Side effects were minor and did not interfere with the course of therapy.