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A Preliminary Report on the Pharmacokinetics of Saccharin in Man: Single Oral Dose Administration
Author(s) -
COLBURN W. A.,
BEKERSKY I.,
BLUMENTHAL H. P.
Publication year - 1981
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/j.1552-4604.1981.tb05692.x
Subject(s) - saccharin , pharmacokinetics , ingestion , oral administration , absorption (acoustics) , urine , plasma concentration , pharmacology , oral dose , chemistry , medicine , physics , acoustics
The pharmacokinetics of saccharin were studied in two human subjects. One male and one female subject ingested a single 100 mg oral dose of saccharin. Absorption was fast and the elimination half‐lives were 1.2 and 6.6 hours for the male and female subject, respectively. Approximately 85% of the oral dose was recovered in the urine as intact saccharin and renal clearance approximated renal plasma flow when corrected for the unbound fraction of saccharin in plasma. Saccharin elimination appears to be related to previous saccharin ingestion, suggesting a high‐retention compartment.