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Bumetanide in Refractory Ascites of Cirrhosis of the Liver: A Comparison with Furosemide
Author(s) -
IBER FRANK L.,
BAUM RICHARD A.
Publication year - 1981
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/j.1552-4604.1981.tb05686.x
Subject(s) - bumetanide , furosemide , ascites , diuresis , natriuresis , medicine , cirrhosis , diuretic , randomized controlled trial , alcoholic liver disease , gastroenterology , chemistry , blood pressure , kidney , sodium , cotransporter , organic chemistry
Bumetanide and furosemide were compared in the treatment of resistant ascites in patients with liver disease of alcoholic origin. In a prospective randomized trial, no significant difference was found in the ability of these two agents to promote natriuresis or diuresis. The duration of action was 12 hours for bumetanide and 6 hours for furosemide, but this difference was of no clinical significance.