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Intramuscular Bumetanide and Furosemide in Congestive Heart Failure
Author(s) -
ABRAMS JONATHAN
Publication year - 1981
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/j.1552-4604.1981.tb05682.x
Subject(s) - bumetanide , furosemide , diuretic , diuresis , loop of henle , heart failure , chemistry , renal sodium reabsorption , sodium , medicine , endocrinology , urine , loop diuretic , reabsorption , pharmacology , kidney , cotransporter , organic chemistry
Bumetanide is a potent loop diuretic that acts at the ascending loop of Henle and proximal renal tubule blocking sodium reabsorption. In a study of 20 patients with congestive heart failure, using the intramuscular route, 40 mg furosemide was compared with 1 mg bumetanide. Both diuretics induced prompt diuresis and solute loss of sodium, potassium, calcium, magnesium, and chloride. In the dosages used in this protocol, furosemide was somewhat more effective than bumetanide with respect to total urine volume and the amounts of solutes excreted into the urine, and acted more rapidly. No serious side effects were observed in either group.