Premium
Clinical Use of Diuretics in Congestive Heart Failure
Author(s) -
HUTCHEON DUNCAN,
VINCENT MARTHA E.,
SANDHU RANDHIR S.
Publication year - 1981
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/j.1552-4604.1981.tb05681.x
Subject(s) - bumetanide , medicine , furosemide , heart failure , hypokalemia , edema , hyponatremia , diuretic , decompensation , anesthesia , cardiology , sodium , cotransporter , chemistry , organic chemistry
Loop diuretics have become indispensable in the management of patients with cardiac decompensation and severe edema. To evaluate the relative potency of these agents, bumetanide and furosemide were compared in 20 patients with edema associated with congestive heart failure in a double‐blind, parallel study design. The dosage of the drugs administered daily for three days was 1 to 2 mg bumetanide or 80 mg furosemide. Both agents were highly effective in reducing the edema and relieving the symptoms of heart failure. Muscle cramps and abdominal pain as side effects were deemed not severe. Laboratory values indicative of mild hypochloremic alkalosis and hyponatremia were observed in two patients. Hypokalemia and reversible eighth‐nerve involvement were not apparent in this study.