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Effects of Indomethacin and Carprofen on Renal Homeostasis in Rheumatoid Arthritis Patients and in Healthy Individuals
Author(s) -
WILLIAMS ROGER L.,
FURST DANIEL E.,
MANDEL H. GEORGE,
NICOLL DIANA,
KONIKOFF JOHN J.,
BENET LESLIE Z.
Publication year - 1981
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/j.1552-4604.1981.tb05656.x
Subject(s) - carprofen , rheumatoid arthritis , medicine , plasma renin activity , furosemide , free water clearance , homeostasis , pharmacology , renal function , endocrinology , blood pressure , renin–angiotensin system
The influence of carprofen and indomethacin on renal salt and water homeostasis was investigated. Carprofen is a new nonsteroidal antiinflammatory drug that is currently undergoing clinical trials in the United States. Both drugs were administered in usual clinical doses to steady state in six healthy individuals and in six individuals with rheumatoid arthritis. Blood pressure, weight, plasma renin activity, urine volume, creatinine clearance, fractional excretion of sodium and potassium, and free water reabsorption were determined. Both drugs were found to suppress plasma renin activity. Indomethacin suppressed plasma renin activity more than carprofen. Neither drug produced clinically significant changes in any of the other parameters. In healthy individuals and in patients with rheumatoid arthritis, renal homeostatic mechanisms may compensate for the salt‐ and water‐retaining effects of nonsteroidal antiinflammatory drugs.