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Cannabinoids in Glaucoma: A Primary Screening Procedure
Author(s) -
ELSOHLY M. A.,
HARLAND E.,
MURPHY J. C.,
WIRTH P.,
WALLER C. W.
Publication year - 1981
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/j.1552-4604.1981.tb02627.x
Subject(s) - cannabinol , cannabidiol , intraocular pressure , statistical significance , medicine , glaucoma , anesthesia , ophthalmology , cannabis , psychiatry
A procedure was developed for screening of cannabinoids for their ability to reduce intraocular pressure (IOP) using normal rabbits. Eight animals per group were used for statistical significance of data. A negative control group was used for every screen as well as a positive control with 1.5 mg/kg Δ 9 ‐THC given intravenously (I.V.). All compounds were tested by I.V. injection and IOP measurements were taken periodically for 5 hours. Data were analyzed by a computer program which takes into account the change in IOP of the control group. Following this procedure we found that Δ 8 ‐THC, Δ 9 ‐THC, cannabinol, and nabilone were active while cannabidiol was inactive.