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The Efficacy and Safety of Nabilone (A Synthetic Cannabinoid) in the Treatment of Anxiety
Author(s) -
FABRE LOUIS F.,
McLENDON DAVID
Publication year - 1981
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/j.1552-4604.1981.tb02617.x
Subject(s) - anxiety , placebo , anxiolytic , cannabinoid , rating scale , medicine , hamilton anxiety rating scale , anesthesia , psychology , psychiatry , alternative medicine , developmental psychology , receptor , pathology
The anxiolytic properties of nabilone, a synthetic cannabinoid resembling the natural cannabinoids, were studied in 25 outpatients suffering from anxiety. The drug was compared with a placebo in a double‐blind manner over a 28‐day treatment period. Patients were seen weekly by the physician and were rated by the Hamilton Rating Scale for Anxiety and the Patient's Global Evaluation as well as by patient‐rated evaluations. The results of the study showed a dramatic improvement in anxiety in the nabilone group when compared with placebo ( P < 0.001). Side effects reported were dry mouth, dry eyes, and drowsiness. Patients did not report any of the subjective “altered state” experience of marihuana.