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Levonantradol‐Induced Inhibition of Acetylcholine Turnover in Rat Hippocampus and Striatum
Author(s) -
COSTA E.,
CHENEY D.L.,
MURRAY T.F.
Publication year - 1981
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/j.1552-4604.1981.tb02603.x
Subject(s) - striatum , acetylcholine , hippocampus , pharmacology , chemistry , neuroscience , medicine , endocrinology , biology , dopamine
The effects of levonantradol, a structurally novel cannabinoid‐related analgesic, on the turnover rate of acetylcholine ( TR ACh ) have been studied in various regions of the rat brain. Levonantradol (0.3 mg/kg subcutaneously) decreases the TR ACh in the hippocampus and striatum by 53 and 30 per cent, respectively. The extent of the reduction in TR Ach is dose dependent, with a maximal decrease of 80 per cent in the hippocampus and 57 per cent in the striatum following the 3 mg/kg dose. In contrast, cortical TR Ach is not affected by any dose of levonantradol. This pattern of activity on cholinergic dynamics elicited by levonantradol is qualitatively similar to that of cannabinoids but differs from that previously reported for narcotic analgesics. Moreover, naltrexone (2 mg/kg intraperitoneally) does not reverse the effects of levonantradol on striatal or hippocampal TR Ach . This pattern of activity on cholinergic dynamics elicited by levonantradol is consistent with a cannabinoid‐like rather than an opioid‐like mode of action.