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Physiologic Observations in a Controlled Clinical Trial of the Antiemetic Effectiveness of 5, 10, and 15 mg of Δ 9 ‐Tetrahydrocannabinol in Cancer Chemotherapy. Ophthalmologic Implications
Author(s) -
LEVITT M.,
WILSON A.,
BOWMAN D.,
KEMEL S.,
KREPART G.,
MARKS V.,
SCHIPPER H.,
THOMSON G.,
WEINERMAN B.,
WEINERMAN R.
Publication year - 1981
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/j.1552-4604.1981.tb02583.x
Subject(s) - antiemetic , medicine , chemotherapy , anesthesia , placebo , intraocular pressure , prochlorperazine , cancer chemotherapy , adverse effect , randomized controlled trial , nausea , surgery , alternative medicine , pathology
One hundred twenty patients about to receive their first treatment with potentially nauseant cancer chemotherapy were randomized to one of six antiemetic treatments: (1) no treatment; (2) placebo; (3) prochlorperazine (PCPZ), 10 mg; (4) Δ 9 ‐tetrahydrocannabinol (THC), 5 mg; (5) THC, 10 mg; (6) THC, 15 mg. Four doses of each medication were given orally at 4‐hour intervals starting 2 hours before chemotherapy. A study nurse was responsible for both objective (nurse) and subjective (patient) symptom questionnaires. Serum levels were obtained at intervals for cross‐reacting cannabinoids. Physiologic measurements including intraocular pressure (IOP), blood pressure, and pulmonary function were also recorded. In summary, the patients were remarkably free of adverse physiologic effects. All intraocular pressures before and after treatment were within the normal range, although a surprising stastistically significant increase in IOP occurred in the group receiving 5 mg THC.