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Hydrochlorothiazide‐Induced 131 I Excretion Facilitated by Salt and Water
Author(s) -
BEYER KARL H.,
FEHR DAVID M.,
GELARDEN R. THOMAS,
WHITE WILLIAM J.,
LANG C. MAX,
VESELL ELLIOT S.
Publication year - 1981
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/j.1552-4604.1981.tb02549.x
Subject(s) - hydrochlorothiazide , thiazide , excretion , chemistry , endocrinology , sodium , medicine , reabsorption , renal physiology , chloride , potassium , diuretic , iodide , kidney , blood pressure , inorganic chemistry , biochemistry , organic chemistry
Salt intake is restricted under clinical conditions for which thiazide diuretics are customarily used. Dietary iodide intake offsets any effect of thiazide on iodide loss. However, our correlation coefficients relating Na + to Cl − to l − excretion indicate that as thiazide administration or sodium chloride intake increases renal Na + and Cl − excretion, l − reabsorption by the nephron coordinately decreases. Increased sodium chloride and water intake by the dog doubled l − excretion rates. Hydrochlorothiazide increased the sodium chloride and water enhanced l − excretion rate as much as eight‐fold. Without added NaCl, hydrochlorothiazide increased the excretion rate of 131 I by three‐ to eightfold, acutely. Within five to seven days after 131 I oral administration, hydrochlorothiazide (1 or 2 mg/kg twice daily) doubled the rate of 131 I disappearance from plasma, reduced the fecal output of 131 I, and increased its rate of renal excretion. When hydrochlorothiazide was administered, as much 131 I was excreted in the first 24 hours as occurred in 48 hours when sodium chloride and water were given without hydrochlorothiazide. Thiazide administration in customary clinical dosage twice a day with substantial sodium chloride and water for the first two days after exposure to 131 I, should therefore facilitate the safe excretion of 131 I. This accelerated removal of 131 I might be enhanced even more if thyroid uptake of 131 I is blocked by administration of potassium iodide, as judged by the greater 131 I recovery from thyroidectomized dogs.