Premium
Comparison of Molindone and Tranylcypromine in the Treatment of Refractory Depression
Author(s) -
SMALL JOYCE G.,
KELLAMS JEFFREY J.,
DENNIS JERRY L.,
MILSTEIN VICTOR
Publication year - 1981
Publication title -
the journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.92
H-Index - 116
eISSN - 1552-4604
pISSN - 0091-2700
DOI - 10.1002/j.1552-4604.1981.tb01780.x
Subject(s) - tranylcypromine , medicine , refractory (planetary science) , depression (economics) , anesthesia , biochemistry , chemistry , physics , monoamine oxidase , astrobiology , economics , macroeconomics , enzyme
A single‐blind parallel study of 20 treatment‐resistant hospitalized depressed patients showed that 10–30 mg/day molindone was more effective and less toxic than 20–30 mg tranylcypromine. Molindone‐treated patients responded during the first week with particular improvement in anxiety symptoms and agitation. Extrapyramidal symptoms developed in half of the patients on molindone, which were effectively managed with amantadine. Early termination from the study because of clinical worsening or side effects occurred in seven patients on tranylcypromine and in none on molindone. These results suggest that molindone in low dosage may be helpful in the management of refractory depression and may have the further advantage of producing a more rapid response to treatment with fewer disabling side effects.